"Coming in, the first half of the year that I've had, I've been hitting it pretty solid and playing pretty solid," Lee said. "I felt like it was close. I feel pretty good with this one."
Lee made a 15-foot birdie putt on the par-3 18th to finish at 14-under 270. She led the last three days, shooting 66-69-67 to take a one-stroke advantage over Nanna Koerstz Madsen into the final round.
Lee won a year after tying for seventh in the inaugural event.
"It's definitely a second-shot golf course," Lee said. "I feel like my iron play is pretty solid, and usually I can be accurate with them. I think it suits me and my game. If my putter is running hot, then I have a good chance."
Sei Young Kim was second. The South Korean birdied Nos. 13-15 to pull within two strokes but parred 16 and 17 and bogeyed the 18th for a 66.
"This golf course is not easy, even regular tournament," Kim said. "The greens are really fast. If I miss the wrong side, it's tough to up-and-down. Even that, I'm very satisfied with my playing. I'm very happy with my score."
Lee easily held on after Kim's rally stalled.
"I was just going to carry on playing my own game," Lee said. "I had a couple birdie opportunities coming in, so I didn't get rattled up or anything."
Annie Park (67) and Morgan Pressel (68) tied for third at 9 under.
Koerstz Madsen shot a 76 to finish 13th at 5 under. She was trying to become the first Danish winner in LPGA Tour history.